CD36 greases up fat secretion and clearance

CD36 is a protein involved in many cellular processes but its role in regulating lipids derived from the intestine was unknown.

CD36-deficient humans have abnormal blood lipid profiles.

In a study appearing online on April 7 in advance of the print publication of the May 1 issue of the Journal of Clinical Investigation, Nada Abumrad and colleagues from Washington University show that CD36 deficiency in the mouse impairs lipid secretion by the small intestine.

These findings raise the possibility that CD36 deficiency, by impairing clearance of fatty acids and triglycerides, may alter susceptibility to diabetes and atherosclerosis.


TITLE: CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood


AUTHOR CONTACT:

Nada A. Abumrad

Washington University, St. Louis, MO USA

Phone: (314) 747-0348; Fax: (314) 444-3432; E-mail: nabumradwustl


View the PDF of this article at: the-jci/article.php?id=21514


Contact: Stacie Bloom

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212 342-4159

Journal of Clinical Investigation

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